Active pharmaceutical ingredients (API) TOP Companies 2020

Published Date : Nov 2022
Author : Pratibha Bhattacharjee
Biography : Sr. content writer at Brand Essence Market Research. Passionate about content curation in the market research vertical. Always striving to create reliable and engaging industry-based content.

Global API market is valued at USD 170.6 billion in 2019 and expected to reach USD 266.82 billion by 2026 with the CAGR of 6.60% over the forecast period. Use of advanced technology in active pharmaceutical ingredient (API) manufacturing, development in biopharmaceutical sector and growth in geriatric population are driving the API market.

The study provides a decisive view of the global API market by segmenting the market based on type of synthesis, type, application and region. based on type of synthesis, APImarket is segmented into biotech and synthetic. based on type, the market is segmented into generic APIs and innovative APIs. based on application, the market is segmented into cardiology, oncology, CNS & neurology, orthopaedic, endocrinology, pulmonology, gastroenterology, nephrology and others.

Increase in the prevalence of chronic diseases such as cancer, cardiovascular diseases, and diabetes and rise in the aging population are propelling the active pharmaceutical ingredients (API) market. As per the National Cancer Institute, the number of cancer incidences is 439.2 per 100,000 men and women per year in USA. According to European Heart Network, CVD accounts for 45% of all deaths in Europe and 37% of all deaths in the EU. Additionally, according to European Society of Cardiology, over one in 20 adults had suffered from diabetes and has high prevalencein middle income countries. In case of Asia—Pacific lung cancer is the major cause of cancer deaths. China alone accounts for over 50 percent of all cancer cases among all countries this region. Changing lifestyle and socio-cultural factors are main reason for growing incidence of cervical cancer. All these statistics shows the severity of chronic diseases, which in turn increases the demand of proper treatment which bolsters the global API market.

With that said, Brandessence Market Research has announced the Top 10 Companies in The API Market.

Sun Pharmaceutical Industries Ltd.:

Sun Pharma’s API productionstarted in 1995 and at present they manufacture APIs at 9 different plants including Hungary, Israel and the U.S. At present they areproducing over 200 APIs including warfarn, carbamazepine and clorazepate. It is one of the most reputed pharmaceutical companies in the world.

Based in India, Sun Pharma functions in diverse segments, including branded generics, complex and pure generics, speciality products, OTC products, antiretrovirals, and active pharmaceutical ingredients (APIs). It have a broad portfolio of over 2,000 products and 300 APIs and the company’s business is expanded to over 100 countries.


TAPI (Teva Active Pharmaceutical Ingredients) is one of the leading manufacturers of APIs in the world at present with more than 75 years of experience and around USD 750 million in third party sales. The company presently holds the industry’s largest portfolio of more than 300 APIs.

TAPI have over 5,000 professionals globally with headquarters situated in Israel. Its production facilities are located in Italy, Hungary, the Czech Republic, Croatia, Israel, India, China, Mexico, Puerto Rico and the United States.

The company’s Research & Development department is currently include over 750 scientists specialized in the fields of chemical synthesis, fermentation, high potency APIs, plant extraction, synthetic peptides, vitamin D derivatives and prostaglandins.


Aurobindo is a technologically integrated global pharmaceutical company. The API business is fully done by technologically advanced API research and development infrastructure that manufacturers new products and is involved with the supply chain right up until their delivery to market.

Aurobindo has a product portfolio of more than 200 APIs with five of their manufacturing facilities examined by reputed regulatory agencies such as the FDA and MHRA.

The company is headquartered in HITEC City, Hyderabad, India. The company’s area of activity comprises six major therapeutic/product areas: antibiotics, anti-retrovirals, cardiovascular products, central nervous system products, gastroenterologicals, and anti-allergics. The company expanded its business in over 125 countries. It has partnership with AstraZeneca and Pfizer.

Pfizer Inc.:

Pfizer Inc. is an American multinational pharmaceutical corporation headquartered in New York City, USA. It is one of the world's largest pharmaceutical companies as well as is listed on the New York Stock Exchange, and its shares have been a component of the Dow Jones Industrial Average since 2004. Pfizer have acquired rank No. 57 on the 2018 Fortune 500 list of the largest United States corporations by total revenue.

The company produces medicines and vaccines in a wide range of medical fields, such as immunology, oncology, cardiology, endocrinology, and neurology. Some of the example of its products are, Lipitor (atorvastatin), used to lower LDL blood cholesterol; Lyrica (pregabalin) for neuropathic pain and fibromyalgia; Diflucan (fluconazole), an oral antifungal medication; Zithromax (azithromycin), an antibiotic; Viagra (sildenafil) for erectile dysfunction; and Celebrex (also Celebra, celecoxib), an anti-inflammatory drug.

Pfizer has been a major provider of specialty APIs for more than 50 years. They make a specific segment of complex compounds of Cortico- and hormonal steroids, Prostaglandins and Antibiotics. Pfizer produces APIs and intermediates in their Kalamazoo, Michigan facility and is pioneered the chemistry used to make complex steroids and hormones.

Novartis International AG:

Novartis International AG is a multinational pharmaceutical company headquartered in Basel, Switzerland and is one of the largest pharmaceutical companies by both market capitalization and sales.

Novartis produces the drugs clozapine, diclofenac, carbamazepine, valsartan, imatinib mesylate, cyclosporine, letrozole, methylphenidate, terbinafine, deferasirox, and others.

In 1996, Ciba-Geigy combined with Sandoz; the pharmaceutical and agrochemical divisions of both companies established Novartis as an independent entity. Novartis is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA),the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The company is a major manufacturer of API products and its API product portfolio contain more than 110 API products.

Merck & Co.Inc.:

Merck & Co., Inc., is an American multinational pharmaceutical company and one of the largest pharmaceutical companies in the world. The company was founded as the United States subsidiary of the German company Merck, and then established as an independent American company in 1917. Though it functions as Merck & Co. in the United States and Canada, the original Merck based in Darmstadt have the rights to the Merck name everywhere else. Merck & Co. is the world's seventh largest pharmaceutical company by market capitalization and revenue. Its headquarters is situated in Kenilworth, New Jersey.

Merck & Co. publishes The Merck Manuals, a series of medical reference books for physicians, nurses, technicians, and veterinarians. These comprises the Merck Manual of Diagnosis and Therapy, the world's best-selling medical reference. Its product portfolio consists of various medicines in varied medical fields such as Vaccines, Thiazide anti-hypertensives, First statin, Antibacterials, Vioxx, Mectizan, Fosamax etc.

With more than 400 pharmaceutical raw materials available globally, the company is an experienced, reliable partner for pharmaceutical manufacturers. Theiractive pharmaceutical ingredient (API)-related portfolio comprises folates and custom synthesis, as well as brand EMPROVE API product family. Besides,they provide activated PEGs that are used for drug conjugation.

Additionally, theyofferinclusive support for all stages of client’s API development and production. Theirhigh-quality APIs are manufactured in accordance with cGMP guidelines and goes through strict quality assurance procedures.



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